Development of a Stochastic Individual Path (SIP) Model for Predicting the Deposition of Pharmaceutical Aerosols: Effects of Turbulence, Polydisperse Aerosol Size, and Evaluation of Multiple Lung Lobes

@inproceedings{Longest2012DevelopmentOA,
  title={Development of a Stochastic Individual Path (SIP) Model for Predicting the Deposition of Pharmaceutical Aerosols: Effects of Turbulence, Polydisperse Aerosol Size, and Evaluation of Multiple Lung Lobes},
  author={Philip Worth Longest and Geng Tian and Renishkumar R. Delvadia and Matthew S. Hindle},
  year={2012}
}
In this study, a new computational fluid dynamics (CFD) modeling approach for pharmaceutical aerosols is further developed by evaluating the effects of turbulence, polydisperse aerosol size distribution, and multiple lung lobes on deposition in the mouth–throat (MT) and entire tracheobronchial (TB) airways. To evaluate a range of respiratory drug delivery conditions, a model dry powder inhaler (DPI; NovolizerTM) and a model spray soft-mist inhaler (SMI; RespimatTM) were considered. The… CONTINUE READING

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