Development of a Physiologically-Based Pharmacokinetic Model of the Rat Central Nervous System

@inproceedings{Badhan2014DevelopmentOA,
  title={Development of a Physiologically-Based Pharmacokinetic Model of the Rat Central Nervous System},
  author={Raj K S Badhan and Marylore Chenel and Jeffrey Penny},
  booktitle={Pharmaceutics},
  year={2014}
}
Central nervous system (CNS) drug disposition is dictated by a drug's physicochemical properties and its ability to permeate physiological barriers. The blood-brain barrier (BBB), blood-cerebrospinal fluid barrier and centrally located drug transporter proteins influence drug disposition within the central nervous system. Attainment of adequate brain-to-plasma and cerebrospinal fluid-to-plasma partitioning is important in determining the efficacy of centrally acting therapeutics. We have… CONTINUE READING