Development of a Novel Simplified PBPK Absorption Model to Explain the Higher Relative Bioavailability of the OROS® Formulation of Oxybutynin

@article{OlivaresMorales2016DevelopmentOA,
  title={Development of a Novel Simplified PBPK Absorption Model to Explain the Higher Relative Bioavailability of the OROS® Formulation of Oxybutynin},
  author={Andr{\'e}s Olivares-Morales and Avijit Ghosh and Leon Aarons and Amin Rostami-Hodjegan},
  journal={The AAPS Journal},
  year={2016},
  volume={18},
  pages={1532-1549}
}
A new minimal Segmented Transit and Absorption model (mSAT) model has been recently proposed and combined with intrinsic intestinal effective permeability (Peff,int) to predict the regional gastrointestinal (GI) absorption (fabs) of several drugs. Herein, this model was extended and applied for the prediction of oral bioavailability and pharmacokinetics of oxybutynin and its enantiomers to provide a mechanistic explanation of the higher relative bioavailability observed for oxybutynin’s… CONTINUE READING
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