Development of a Murine Infection Model with Leishmania killicki, Responsible for Cutaneous Leishmaniosis in Algeria: Application in Pharmacology

  title={Development of a Murine Infection Model with Leishmania killicki, Responsible for Cutaneous Leishmaniosis in Algeria: Application in Pharmacology},
  author={Naouel Eddaikra and Ihcene Kherachi Djenad and Sihem Benbetka and Razika Benikhlef and Khatima A{\"i}t-Oudhia and Farida Moulti-Mati and Bruno Oury and Denis Sereno and Zoubir Harrat},
  journal={BioMed Research International},
In Algeria, Leishmania infantum, Leishmania major, and Leishmania killicki (Leishmania tropica) are responsible for cutaneous leishmaniosis. We established a murine model of L. killicki infection to investigate its infective capacity, some immunophysiopathological aspects, and its suitability for pharmacological purposes. Following the injection of L. major or L. killicki metacyclic promastigotes in the ear dermis of BALB/c mice, the course of infection was followed. The infection with L… 

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