Development of a Murine Infection Model with Leishmania killicki, Responsible for Cutaneous Leishmaniosis in Algeria: Application in Pharmacology

@article{Eddaikra2016DevelopmentOA,
  title={Development of a Murine Infection Model with Leishmania killicki, Responsible for Cutaneous Leishmaniosis in Algeria: Application in Pharmacology},
  author={Naouel Eddaikra and Ihcene Kherachi Djenad and S Benbetka and Razika Benikhlef and Khatima A{\"i}t-Oudhia and Farida Moulti-Mati and Bruno Oury and Denis Sereno and Zoubir Harrat},
  journal={BioMed Research International},
  year={2016},
  volume={2016}
}
In Algeria, Leishmania infantum, Leishmania major, and Leishmania killicki (Leishmania tropica) are responsible for cutaneous leishmaniosis. We established a murine model of L. killicki infection to investigate its infective capacity, some immunophysiopathological aspects, and its suitability for pharmacological purposes. Following the injection of L. major or L. killicki metacyclic promastigotes in the ear dermis of BALB/c mice, the course of infection was followed. The infection with L… 
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Leishmania tropica: What we know from its experimental models.
TLDR
Hamsters are the best animal model for L. tropica infection, with the drawback of being outbred hence not suitable for many studies, and the dose, strain, routes of inoculation, and sex of the host are among the factors affecting disease outcome of this species.
Updates on Geographical Dispersion of Leishmania Parasites Causing Cutaneous Affections in Algeria
TLDR
A set of Giemsa-stained smears prepared from skin lesions of the patients suspected to have cutaneous leishmaniasis (CL) in various geographical areas in Algeria provided additional information on the geographical extension of CL caused by L. tropica and L. infantum in Algeria.
Antimonial susceptibility and in vivo behaviour of Leishmania major isolates collected in Algeria before and after treatment.
TLDR
The link between antimonial susceptibility and in vivo behaviour in Leishmania major isolates collected before and after treatment in Algeria was explored and no relationship was observed between in vitro antimony resistance and parasite fitness in the murine model.
Noninvasive Biological Samples to Detect and Diagnose Infections due to Trypanosomatidae Parasites: A Systematic Review and Meta-Analysis
TLDR
A systematic review on clues evidencing the presence of parasites, genetic material, antibodies, and antigens in body secretions, appendages, or the organs or proximal tissues that produce these materials for the diagnosis of infections caused by Leishmania and by other Trypanosomatidae parasites pins significant gaps that need to be filled.
Leishmania antimony resistance/ susceptibility in Algerian foci
TLDR
Algeria is one of the most endemic countries for cutaneous and visceral forms of leishmaniosis and has a major public health impact, according to the World Health Organization.
Biological assay

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