Development of a Multi-Step Leukemogenesis Model of MLL-Rearranged Leukemia Using Humanized Mice

@inproceedings{Moriya2012DevelopmentOA,
  title={Development of a Multi-Step Leukemogenesis Model of MLL-Rearranged Leukemia Using Humanized Mice},
  author={Kunihiko Moriya and Makiko Suzuki and Yohei Watanabe and Takeshi Takahashi and Yoko Aoki and Toru Uchiyama and Satoru Kumaki and Yoji Sasahara and Masayoshi Minegishi and Shigeo Kure and Shigeru Tsuchiya and Kazuo Sugamura and Naoto Ishii},
  booktitle={PloS one},
  year={2012}
}
Mixed-lineage-leukemia (MLL) fusion oncogenes are intimately involved in acute leukemia and secondary therapy-related acute leukemia. To understand MLL-rearranged leukemia, several murine models for this disease have been established. However, the mouse leukemia derived from mouse hematopoietic stem cells (HSCs) may not be fully comparable with human leukemia. Here we developed a humanized mouse model for human leukemia by transplanting human cord blood-derived HSCs transduced with an MLL-AF10… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 12 extracted citations

The molecular basis of myeloid malignancies

Proceedings of the Japan Academy. Series B, Physical and biological sciences • 2014

References

Publications referenced by this paper.
Showing 1-10 of 45 references

( MLL ) fusion protein collaborates with Ras to induce acute leukemia through aberrant Hox expression and Raf activation

A Rizo, SJ Horton, S Olthof, B Dontje, A Ausema
2010

Similar Papers

Loading similar papers…