Development of a DNA sensor using a molecular logic gate

  title={Development of a DNA sensor using a molecular logic gate},
  author={Debajyoti Bhattacharjee and Dibyendu Dey and Sekhar Chakraborty and Syed Arshad Hussain and Sangram Sinha},
  journal={Journal of Biological Physics},
This communication reports the increase in fluorescence resonance energy transfer (FRET) efficiency between two laser dyes in the presence of deoxyribonucleic acid (DNA). Two types of molecular logic gates have been designed where DNA acts as input signal and fluorescence intensity of different bands are taken as output signal. Use of these logic gates as a DNA sensor has been demonstrated. 

Development of a sensor to study the DNA conformation using molecular logic gates.

Biomacromolecular logic gate, encoder/decoder and keypad lock based on DNA damage with electrochemiluminescence and electrochemical signals as outputs.

Based on the damage of natural DNA, a 3-input/4-output logic gate system and other biomacromolecular devices, such as a 2-to-1 encoder, a 1-to-2 decoder and a keypad lock, were developed using

Construction of a fuzzy and Boolean logic gates based on DNA.

This work shows the successful construction of a small DNA-based logic gate complex that produces fluorescent outputs corresponding to the operation of the six Boolean logic gates AND, NAND, OR, NOR, XOR, and XNOR.

Hydrogen bonding network as a logic gate

  • R. Rusev
  • Computer Science
    2017 XXVI International Scientific Conference Electronics (ET)
  • 2017
A circuit consisting of four- and five-terminal block elements is developed to imitate the behavior of hydrogen bonding networks in the β-lactamase protein. The circuit is implemented in Cadence

Reversible Multicomponent AND Gate Triggered by Stoichiometric Chemical Pulses Commands the Self-Assembly and Actuation of Catalytic Machinery.

The present work demonstrates the operation of a reversible supramolecular gate, i.e., an ensemble of various components linked by chemical communication, which is triggered by stoichiometric



Photo-pH dually modulated fluorescence switch based on DNA spatial nanodevice.

By integrating a photoregulated fluorescent switch and a DNA-based nanomachine, the distance-dependent FRET process between fluorescein and photochromic moieties can be further modulated by the spatial output of a unique proton-driven DNA manomachine.

A molecular photoionic AND gate based on fluorescent signalling

A receptor is described that operates as a logic device with two input channels: the fluorescence signal depends on whether the molecule binds hydrogen ions, sodium ions or both and the input/output characteristics of this molecular device correspond to those of an AND gate.

Digital analysis of protein properties by an ensemble of DNA quadruplexes.

Combination of molecular Boolean logic with combinatorial sensing is demonstrated as a general strategy to realizing small scale, real time diagnosis of a variety of protein samples.

A New FRET-Based Sensitive DNA Sensor for Medical Diagnostics using PNA Probe and Water-Soluble Blue Light Emitting Polymer

A reliable, fast, and low-cost biosensor for medical diagnostics using DNA sequence detection has been developed and tested for the detection of the bacterium “Bacillus anthracis.” In this sensor,

Fluorescein provides a resonance gate for FRET from conjugated polymers to DNA intercalated dyes.

These experiments show that the proximity and conformational freedom of Fl provide a FRET gate to dyes intercalated within DNA which are optically amplified by the properties of the conjugated polymer.

Immobilization of single strand DNA on solid substrate

Unambiguous detection of target DNAs by excimer-monomer switching molecular beacons.

A new class of molecular beacons were developed in which pyrene fluorophores were connected both at 3' and 5' ends of a single-stranded oligonucleotide, which can detect target 19-mer DNAs and can discriminate the targets from their single-nucleotide mismatches at 1 nM concentration.

DNA hybridization assays using metal-enhanced fluorescence.

Chemical approaches to molecular logic elements for addition and subtraction.

Recent developments to attain molecular systems with increased logic capabilities is described, including bioinspired systems based on DNA and enzymes, as well as chemical molecular logic gates.

Molecular 2:1 digital multiplexer.

A porphyrin linked to two photochromic moieties performs as a 2:1 digital multiplexer (MUX) that takes heat and red light as the two inputs and selects whether the output (porphyrin fluorescence) reports the state of in 1 or in 2.