Development of a D-xylose fermenting and inhibitor tolerant industrial Saccharomyces cerevisiae strain with high performance in lignocellulose hydrolysates using metabolic and evolutionary engineering

@inproceedings{Demeke2013DevelopmentOA,
  title={Development of a D-xylose fermenting and inhibitor tolerant industrial Saccharomyces cerevisiae strain with high performance in lignocellulose hydrolysates using metabolic and evolutionary engineering},
  author={Mekonnen M. Demeke and Heiko Dietz and Yingying Li and Maria Remedios Foulqui{\'e}-Moreno and Sarma Mutturi and Sylvie Deprez and Tom den Abt and Beatriz Monge Bonini and Gunnar Lid{\'e}n and F. A. G. Dumortier and Alex Verplaetse and Eckhard Boles and Johan M Thevelein},
  booktitle={Biotechnology for biofuels},
  year={2013}
}
BACKGROUND The production of bioethanol from lignocellulose hydrolysates requires a robust, D-xylose-fermenting and inhibitor-tolerant microorganism as catalyst. The purpose of the present work was to develop such a strain from a prime industrial yeast strain, Ethanol Red, used for bioethanol production. RESULTS An expression cassette containing 13 genes including Clostridium phytofermentans XylA, encoding D-xylose isomerase (XI), and enzymes of the pentose phosphate pathway was inserted in… CONTINUE READING
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