Development of a 3D human in vitro skin co-culture model for detecting irritants in real-time.

Abstract

Tissue engineered materials for clinical purposes have led to the development of in vitro models as alternatives to animal testing. The aim of this study was to understand the paracrine interactions arising between keratinocytes and fibroblasts for detecting and discriminating between an irritant-induced inflammatory reaction and cytotoxicity. We used two… (More)
DOI: 10.1002/bit.22742

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@article{Cantn2010DevelopmentOA, title={Development of a 3D human in vitro skin co-culture model for detecting irritants in real-time.}, author={Isabel Cant{\'o}n and Dallas Cole and E Helen Kemp and P F Watson and Jirapat Chunthapong and A. J. Ryan and Sasha MacNeil and J. W. Haycock}, journal={Biotechnology and bioengineering}, year={2010}, volume={106 5}, pages={794-803} }