Development of Three Orthogonal Assays Suitable for the Identification and Qualification of PIKfyve Inhibitors.

Abstract

FYVE-type zinc finger-containing phosphoinositide kinase (PIKfyve) catalyzes the formation of phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2) from phosphatidylinositol 3-phosphate (PI(3)P). PIKfyve has been implicated in multiple cellular processes, and its role in the regulation of toll-like receptor (TLR) pathways and the production of proinflammatory… (More)
DOI: 10.1089/adt.2017.790

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