Development of Th1 and Th2 populations and the nature of immune responses to hepatitis B virus DNA vaccines can be modulated by codelivery of various cytokine genes.

@article{Chow1998DevelopmentOT,
  title={Development of Th1 and Th2 populations and the nature of immune responses to hepatitis B virus DNA vaccines can be modulated by codelivery of various cytokine genes.},
  author={Yen Hung Chow and B. L. Chiang and Young Lim Lee and W. K. Chi and W. C. Lin and Y-T. Chen and M. H. Tao},
  journal={Journal of immunology},
  year={1998},
  volume={160 3},
  pages={
          1320-9
        }
}
In this study, we provide direct evidence that the magnitude and nature of the immune response to a DNA vaccine can be differentially regulated by codelivery of various mouse cytokine genes. Mice immunized with a hepatitis B virus (HBV) DNA vaccine and the IL-12 or IFN-gamma gene exhibited a significant enhancement of Th1 cells and increased production of anti-HBV surface IgG2a Ab, as well as a marked inhibition of Th2 cells and decreased production of IgG1 Ab. In contrast, coinjection of the… CONTINUE READING

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