Development of TLR9 agonists for cancer therapy.

  title={Development of TLR9 agonists for cancer therapy.},
  author={Arthur M. Krieg},
  journal={The Journal of clinical investigation},
  volume={117 5},
In vertebrates, the TLRs are a family of specialized immune receptors that induce protective immune responses when they detect highly conserved pathogen-expressed molecules. Synthetic agonists for several TLRs, including TLR3, TLR4, TLR7, TLR8, and TLR9, have been or are being developed for the treatment of cancer. TLR9 detects the unmethylated CpG dinucleotides prevalent in bacterial and viral DNA but not in vertebrate genomes. As discussed in this Review, short synthetic oligodeoxynucleotides… CONTINUE READING
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