Development of T cell receptor alpha beta-bearing T cells in the submersion organ culture of murine fetal thymus at high oxygen concentration.

@article{Watanabe1993DevelopmentOT,
  title={Development of T cell receptor alpha beta-bearing T cells in the submersion organ culture of murine fetal thymus at high oxygen concentration.},
  author={Yoshiteru Watanabe and Yoshimoto Katsura},
  journal={European journal of immunology},
  year={1993},
  volume={23 1},
  pages={200-5}
}
Organ culture (OC) of murine fetal thymuses on a membrane filter floating on the medium has been used as an important strategy in studies of the mechanism of T cell development. On the other hand, the submersion organ culture (S-OC) system, in which fetal thymus lobes are submerged in the culture medium, is not popularly used because the growth of T cells is much lower than that in OC at the air-medium border (AMB-OC). In the present work, we tried to culture the fetal thymuses in the S-OC… CONTINUE READING

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