• Corpus ID: 208193742

Development of Synthetic Cell Differentiation Agent Formulations for the Prevention and Therapy of Cancer via Targeting of Cancer Stem Cells

  title={Development of Synthetic Cell Differentiation Agent Formulations for the Prevention and Therapy of Cancer via Targeting of Cancer Stem Cells},
  author={Ming C. Liau and Paul A. Fruehauf and Zhong-Hui Zheng and John P Fruehauf},
The association of methylation enzymes with telomerase constitutes a unique abnormality of cancer cells. This abnormality locks methylation enzymes in an exceptionally stable and active state so that hypomethylation of nucleic acids necessary for the cells to undergo Terminal Differentiation (TD) cannot take place. Human body produces metabolites that are able to eliminate telomerase from abnormal methylation enzymes of cancer cells to allow TD to proceed. Cell Differentiation Agent-2 (CDA-2… 

In Pursuance of Differentiation Inducers to Combat Cancer via Targeting of Abnormal Methylation Enzymes

Cell differentiation agent-2 was a promising hypomethylating agent approved by the Chinese FDA for the therapy of MDS in China and Prostaglandin E2 attracted the attention because it was implicated to involve in wound healing, which is a major biological mission.

Arachidonic acid and its metabolites as the surveillance differentiation inducers to protect healthy people from becoming cancer patients

It requires only a single hit by silencing TET-1 enzyme to convert PSCs to CSCs, which can be easily accomplished by P SCs since these cells are equipped with abnormally active Methylation Enzymes.

The Winner of the Contest to Eradicate Cancer Stem Cells Wins the Contest of Cancer Therapies: The Winner is Cell Differentiation Agent Formulations

It has been widely accepted that most human cancers had a small subpopulation of cancer stem cells (CSCs) which were closely related to progenitor stem cells (PSCs) based on cell features and

No Scar as an Indication of Perfect Wound Healing, Ugly Scar as Imperfect Wound Healing and Cancer as Failed Wound Healing

The study of wound healing is helpful to heal wound with no scar and to search for a more appropriate strategy of cancer therapy.



Abnormal Methylation Enzymes: A Selective Molecular Target for Differentiation Therapy of Cancer

Many abnormal behaviors characteristic of cancer cells disappear naturally as a consequence of differentiation induced by CDA-Ⅱ, which include abnormal expression of oncogenes, silencing of suppressor genes, drug resistance, metastasis, telomerase, and tumor markers.

Study on Potentiation of ATRA Activity in HL-60 Cells by Targeting Methylation Enzymes

It is reported here that DHIs that destabilize SAHH potentiate the capacity of ATRA to induce terminal differentiation in both sensitive and resistant HL-60 cells in vitro, and combined with agents that inhibit DNMT shows improved in vitro and clinical activity against AML.

Isolation and identification of chemotherapy‐enriched sphere‐forming cells from a patient with gastric cancer

Targeting chemotherapy‐enriched CSCs as chemo‐resistance cells observed in GC patients can provide more effective therapeutic strategies compared to untreated patients.

Multidrug Efflux Pumps and Cancer Stem Cells: Insights Into Multidrug Resistance and Therapeutic Development

A better understanding of the mechanisms involved in the resistance of stem cells to chemotherapy could lead to the discovery of new therapeutic targets and improvement of current anticancer strategies.

Loss of 5‐hydroxymethylcytosine is accompanied with malignant cellular transformation

The findings suggest that the amount of 5‐hmC in tumors is often reduced via various mechanisms, including the downregulation of TET1, and the critical roles of aberrant DNA demethylation for oncogenic processes in solid tissues are suggested.

WNT pathway inhibitor pyrvinium pamoate inhibits the self-renewal and metastasis of breast cancer stem cells.

PP inhibited proliferation of different subtypes of breast cancer cells and caused inhibition of WNT pathway activity and stemness regulator expression including NANOG, SOX2 and OCT4, which were inherently upregulated in the BCSCs as compared with the bulk of cells within the tumor.

Antitumor Effect of the Atypical Retinoid ST1926 in Acute Myeloid Leukemia and Nanoparticle Formulation Prolongs Lifespan and Reduces Tumor Burden of Xenograft Mice

It is shown that sub-μmol/L concentrations of ST1926 potently and selectively inhibited the growth of ATRA-resistant AML cell lines and primary blasts, and in vivoST1926-NP antitumor effects were achieved at four fold lower concentrations than the naked drug.

Cancer stem cells – old concepts, new insights

Novel insights in cancer stem cell research suggest another layer of complexity in the process of malignant transformation and preservation, and illustrates that the CSC model can be considered an extension of the classic genetic model rather than a contradictory theory.

Phenylacetate in chemoprevention: in vitro and in vivo suppression of 5-aza-2'-deoxycytidine-induced carcinogenesis.

Phenylacetate and its precursor suitable for oral administration, phenylbutyrate, may represent a new class of chemopreventive agents, the efficacy and safety of which should be further evaluated.