Development of ST-246® for Treatment of Poxvirus Infections

  title={Development of ST-246® for Treatment of Poxvirus Infections},
  author={Robert Jordan and Janet M. Leeds and Shanthakumar R. Tyavanagimatt and Dennis E. Hruby},
ST-246 (Tecovirimat) is a small synthetic antiviral compound being developed to treat pathogenic orthopoxvirus infections of humans. The compound was discovered as part of a high throughput screen designed to identify inhibitors of vaccinia virus-induced cytopathic effects. The antiviral activity is specific for orthopoxviruses and the compound does not inhibit the replication of other RNA- and DNA-containing viruses or inhibit cell proliferation at concentrations of compound that are antiviral… CONTINUE READING