Development of Rutin Ethosomes for Enhanced Skin Permeation

  title={Development of Rutin Ethosomes for Enhanced Skin Permeation},
  author={Anju K. Dhiman and Deepika Singh and Kaneez Fatima and Ghazala Zia},
  journal={International Journal of Traditional Medicine and Applications},
Materials and Methods: Rutin ethosomes using butylated hydroxytoulene (BHT) as permeation enhancer were prepared by cold method. The optimization of rutin ethosomes were done by using 23 factorial design with the help of design expert software (version 8.0). The optimized rutin ethosomes formulation were then characterized for vesicular shape, size of the particle and the size distribution by using scanning electron microscopy, zeta potential, entrapment efficiency and stability studies. The… 

Quercetin- and Rutin-Containing Electrospun Cellulose Acetate and Polyethylene Glycol Fibers with Antioxidant and Anticancer Properties

Innovative fibrous materials from cellulose derivative, cellulose acetate (CA) and water-soluble polyether, polyethylene glycol (PEG) loaded with natural biologically active compounds (BAC),

Ethosomes as Novel Drug Delivery System: A Review

Various aspect of ethosome including their advantages, disadvantages, ethosomal system types, composition of ethosomes, mechanism of penetration, physicochemical characterization, evaluation & applications are reviewed.

A Newfangled Collagenase Inhibitor Topical Formulation Based on Ethosomes with Sambucus nigra L. Extract

This study demonstrates the potential use of S. nigra extract incorporated in ethosomes as a potential cosmeceutical ingredient and on further studies should be performed to better understand the impact of sambucus nigra compounds on skin care over the time.



Ethosome for Enhanced Transdermal Drug Delivery of Aceclofenac

The result advocates the potential of ethosome formulation to treat rheumatic disease where facilitated penetration of the drug into muscle and synovial fluid is desirable and can expect the ethosomal formulation to be safe and very efficient as a drug carrier for systemic as well as topical delivery of drug.

Preparation and In vitro Evaluation of Ethosomal Total Alkaloids of Sophora alopecuroides Loaded by a Transmembrane pH-Gradient Method

Results suggested transmembrane pH gradient active loading method may be an effective method to prepare alkaloids ethosomal systems at the temperatures below the Tc of PC.


The aim of the study was to evaluate the effect of different permeation enhancers in the transdermal permeation of flavonoids. A weed plant named Chromolaena odorata have been employed as the

Mechanism of bacitracin permeation enhancement through the skin and cellular membranes from an ethosomal carrier.

  • B. GodinE. Touitou
  • Biology
    Journal of controlled release : official journal of the Controlled Release Society
  • 2004

Ethosomes - novel vesicular carriers for enhanced delivery: characterization and skin penetration properties.

Chemical Penetration Enhancers for Transdermal Drug Delivery Systems

In this review, this review has discussed the chemical penetration enhancement technology for transdermal drug delivery as well as the probable mechanisms of action.

Antioxidant, Anti-inflammatory and Cytotoxicity of Phaleria macrocarpa (Boerl.) Scheff Fruit

The results indicated the possible application of P. macrocarpa fruit as a source of bioactive compounds, potent as an antioxidant, anti inflammatory and cytotoxic agents.

Drug-Loaded Biocompatible Nanocarriers Embedded in Poloxamer 407 Hydrogels as Therapeutic Formulations

The state of the art of the most important mixed systems made up of colloidal carriers localized within a P407 hydrogel will be provided in order to illustrate the possibility of obtaining a controlled release of the entrapped drugs and an increase in their therapeutic efficacy as a function of the biomaterial used.

Partial Dominance, Overdominance, Epistasis and QTL by Environment Interactions Contribute to Heterosis in Two Upland Cotton Hybrids

It was concluded that partial dominance, overdominance, epistasis, and QEs all contribute to heterosis in Upland cotton, and thatpartial dominance resulting from single loci and epistasis play a relatively more important role than other genetic effects in heterosis.

Formulation and Evaluation of Diclofenac Potassium Ethosomes

The potency of the ethosomes is suggested to enhance the therapeutic effect and minimize the side effects of Diclofenac Potassium to improve the systemic availability through the transdermal route.