Development of Promising Thiopyrimidine-Based Anti-cancer and Antimicrobial Agents: Synthesis and QSAR Analysis.

@article{Anwar2018DevelopmentOP,
  title={Development of Promising Thiopyrimidine-Based Anti-cancer and Antimicrobial Agents: Synthesis and QSAR Analysis.},
  author={Manal Mohamed Anwar and Yasmin M Syam and Eman R. Kotb and Samia A Elseginy},
  journal={Mini reviews in medicinal chemistry},
  year={2018}
}
New hybrids of thiopyrimidine-five/six heterocyclic rings were synthesized and in vitro evaluated for their antiproliferative activity against three human cancer cell lines, namely HCT116 (human colorectal carcinoma), PC-3 (human prostate adenocarcinoma) and HepG2 (human liver carcinoma) cell lines. The most potency was elicited by the target candidates… CONTINUE READING