Development of Pancreatic Acinar Cell Metaplasia After Successful Administration of Omeprazole for 6 Months in Rats

@article{Hagiwara2006DevelopmentOP,
  title={Development of Pancreatic Acinar Cell Metaplasia After Successful Administration of Omeprazole for 6 Months in Rats},
  author={Tadashi Hagiwara and PhD Ken-ichi Mukaisho and Zhi-Qiang Ling and PhD Hiroyuki Sugihara and PhD Takanori Hattori},
  journal={Digestive Diseases and Sciences},
  year={2006},
  volume={52},
  pages={1219-1224}
}
Long-term use of proton pump inhibitors (PPIs) has been reported to worsen corpus atrophic gastritis in patients with Helicobacter pylori infection. On the other hand, PPIs have been associated with fundic gland-type gastric polyps and various histological changes. In the present study, we attempted to establish a protocol for omeprazole (OPZ) administration to rats over a longer period and examined the morphological changes in the gastric mucosa after administration of OPZ for 6 months. A… CONTINUE READING

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