Development of PK- and PBPK-based modeling tools for derivation of biomonitoring guidance values

@article{Bartels2012DevelopmentOP,
  title={Development of PK- and PBPK-based modeling tools for derivation of biomonitoring guidance values},
  author={M. Bartels and D. Rick and E. Lowe and G. Loizou and P. Price and M. Spendiff and S. Arnold and J. Cocker and N. Ball},
  journal={Computer methods and programs in biomedicine},
  year={2012},
  volume={108 2},
  pages={773-88}
}
There are numerous programs ongoing to analyze environmental exposure of humans to xenobiotic chemicals via biomonitoring measurements (e.g.: EU ESBIO, COPHES; US CDC NHANES; Canadian Health Measures Survey). The goal of these projects is to determine relative trends in exposure to chemicals, across time and subpopulations. Due to the lack of data, there is… CONTINUE READING