Development of PEGylated peptide probes conjugated with (18)F-labeled BODIPY for PET/optical imaging of MT1-MMP activity.

@article{Kondo2015DevelopmentOP,
  title={Development of PEGylated peptide probes conjugated with (18)F-labeled BODIPY for PET/optical imaging of MT1-MMP activity.},
  author={Naoya Kondo and Takashi Temma and Jun Deguchi and Kohei Sano and Masahiro Ono and Hideo Saji},
  journal={Journal of controlled release : official journal of the Controlled Release Society},
  year={2015},
  volume={220 Pt A},
  pages={476-483}
}
Since the processing activity of the matrix metalloproteinase MT1-MMP regulates various cellular functions such as motility, invasion, growth, differentiation and apoptosis, precise in vivo evaluation of MT1-MMP activity in cancers can provide beneficial information for both basic and clinical studies. For this purpose, we designed a cleavable Positron Emission Tomography (PET)/optical imaging probe consisting of BODIPY650/665 and polyethylene glycol (PEG) conjugated to opposite ends of MT1-MMP… CONTINUE READING