Development of Novel 3D-QSAR Combination Approach for Screening and Optimizing B-Raf Inhibitors in silico

Abstract

B-Raf is a member of the RAF family of serine/threonine kinases: it mediates cell division, differentiation, and apoptosis signals through the RAS-RAF-MAPK pathway. Thus, B-Raf is of keen interest in cancer therapy, such as melanoma. In this study, we propose the first combination approach to integrate the pharmacophore (PhModel), CoMFA, and CoMSIA models… (More)
DOI: 10.1021/ci100351s

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Cite this paper

@article{Shih2011DevelopmentON, title={Development of Novel 3D-QSAR Combination Approach for Screening and Optimizing B-Raf Inhibitors in silico}, author={Kuei-Chung Shih and Chun-Yuan Lin and Jiayi Zhou and Hsiao-Chieh Chi and Ting-Shou Chen and Chun-Chung Wang and Hsiang-Wen Tseng and Chuan Yi Tang}, journal={Journal of chemical information and modeling}, year={2011}, volume={51 2}, pages={398-407} }