Development of N,O-(carboxymethyl)chitosan/collagen matrixes as a wound dressing.

  title={Development of N,O-(carboxymethyl)chitosan/collagen matrixes as a wound dressing.},
  author={Ray-Neng Chen and Gen-Ming Wang and Chien-Ho Chen and H Ho and M J Sheu},
  volume={7 4},
In an attempt to accelerate wound healing by stimulating the recruitment of fibroblasts and improve the mechanical properties of collagen matrixes, N,O-(carboxymethyl)chitosan (NOCC) was incorporated into the backbone of a collagen (COL) matrix without or with chondroitin sulfate (CS) or an acellular dermal matrix (ADM). The result of a cell migration study demonstrated that the migration of fibroblasts was significantly enhanced by NOCC in a concentration-dependent manner. In the analysis with… CONTINUE READING

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