Development of Multigene Expression Signature Maps at the Protein Level from Digitized Immunohistochemistry Slides

@inproceedings{Metzger2012DevelopmentOM,
  title={Development of Multigene Expression Signature Maps at the Protein Level from Digitized Immunohistochemistry Slides},
  author={Gregory J. Metzger and Stephen C. Dankbar and Jonathan C Henriksen and Anthony E. Rizzardi and Nikolaus K. Rosener and Stephen C. Schmechel},
  booktitle={PloS one},
  year={2012}
}
Molecular classification of diseases based on multigene expression signatures is increasingly used for diagnosis, prognosis, and prediction of response to therapy. Immunohistochemistry (IHC) is an optimal method for validating expression signatures obtained using high-throughput genomics techniques since IHC allows a pathologist to examine gene expression at the protein level within the context of histologically interpretable tissue sections. Additionally, validated IHC assays may be readily… CONTINUE READING