Development of Immune Functions Related to Allergic Mechanisms in Young Children

@article{Koning1996DevelopmentOI,
  title={Development of Immune Functions Related to Allergic Mechanisms in Young Children},
  author={Henk Koning and Miranda R. M. Baert and Arnold Pieter Oranje and Huub F J Savelkoul and Herman J. Neijens},
  journal={Pediatric Research},
  year={1996},
  volume={40},
  pages={363-375}
}
The newborn immune system differs quantitatively and functionally from that of adults. Development of the immune system has important implications for childhood diseases. The immaturity of the immune system in the first years of life may contribute to failure of tolerance induction and in the development of allergic disease. T cell function is diminished, especially the capacity to produce cytokines; production of interferon (IFN)-γ, and IL-4 is strongly reduced. IFN-γ has been found to be even… CONTINUE READING

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