Development of HER2-specific chimeric antigen receptor T cells for the treatment of breast-to-brain metastasis

Abstract

Adoptive transfer of chimeric antigen receptor (CAR)engineered T cells has demonstrated robust and durable clinical efficacy in patients with CD19+ B cell malignancies. Broader application of this approach to brain and other advanced solid tumors is an immediate goal for the field and is presently under intense investigation. In 2014, 40,000 individuals in… (More)

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