Development of GABA neurons in dissociated cell culture of rat cerebral cortex

@article{Hauser1979DevelopmentOG,
  title={Development of GABA neurons in dissociated cell culture of rat cerebral cortex},
  author={Kathleen L. Hauser and Vladimir Josef Balcar and Robert Bernasconi},
  journal={Brain Research Bulletin},
  year={1979},
  volume={5},
  pages={37-41}
}
Abstract Cortical neurons dissociated from newborn rat brain were maintained on supporting glial monolayers in the presence of the mitotic inhibitor, FUdR. The ability of this type of primary culture (NG) to synthesize, store, metabolize, accumulate and release GABA was compared to that of neuron-free glial monolayers (G) cultured under the same conditions. While NG cultures synthesized and stored GABA, there was little GABA, or GABA-synthesizing activity (GAD) in G cultures. In contrast… CONTINUE READING
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