Development of Foxp3(+) regulatory t cells is driven by the c-Rel enhanceosome.

@article{Ruan2009DevelopmentOF,
  title={Development of Foxp3(+) regulatory t cells is driven by the c-Rel enhanceosome.},
  author={Qingguo Ruan and Vasumathi Kameswaran and Yukiko Tone and Li Li and Hsiou-chi Liou and M ichael Greene and Masahide Tone and Youhai H Chen},
  journal={Immunity},
  year={2009},
  volume={31 6},
  pages={932-40}
}
Regulatory T (Treg) cells are essential for maintaining immune homeostasis. Although Foxp3 expression marks the commitment of progenitors to Treg cell lineage, how Treg cells are generated during lymphocyte development remains enigmatic. We report here that the c-Rel transcription factor controlled development of Treg cells by promoting the formation of a Foxp3-specific enhanceosome. This enhanceosome contained c-Rel, p65, NFAT, Smad, and CREB. Although Smad and CREB first bound to Foxp3… CONTINUE READING
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