Development of Ewing's sarcoma from primary bone marrow-derived mesenchymal progenitor cells.

@article{Riggi2005DevelopmentOE,
  title={Development of Ewing's sarcoma from primary bone marrow-derived mesenchymal progenitor cells.},
  author={Nicol{\`o} Riggi and Luisa Cironi and Paolo Provero and Mario-Luca Suv{\`a} and Konstantinos Kaloulis and Carlos Garc{\'i}a-Echeverr{\'i}a and Francesco Hoffmann and Andreas Trumpp and Ivan Stamenkovic},
  journal={Cancer research},
  year={2005},
  volume={65 24},
  pages={11459-68}
}
Ewing's sarcoma is a member of Ewing's family tumors (EFTs) and the second most common solid bone and soft tissue malignancy of children and young adults. It is associated in 85% of cases with the t(11;22)(q24:q12) chromosomal translocation that generates fusion of the 5' segment of the EWS gene with the 3' segment of the ETS family gene FLI-1. The EWS-FLI-1 fusion protein behaves as an aberrant transcriptional activator and is believed to contribute to EFT development. However, EWS-FLI-1… CONTINUE READING
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