Development of ELISAs for irinotecan and its active metabolite SN-38.

@article{Saita2000DevelopmentOE,
  title={Development of ELISAs for irinotecan and its active metabolite SN-38.},
  author={Tetsuya Saita and Hiroshi Fujito and Masato Mori},
  journal={Biological \& pharmaceutical bulletin},
  year={2000},
  volume={23 8},
  pages={
          911-6
        }
}
Two highly sensitive and specific enzyme-linked immunosorbent assays (ELISAs) for the determination of 7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxy-camptothecin (irinotecan) and 7-ethyl-10-hydroxycamptothecin (SN-38), an active metabolite of irinotecan, were developed, which are capable of measuring as low as 16 and 160 pg of each drug/ml, respectively. Anti-irinotecan antibody was obtained by immunizing rabbits with irinotecan conjugated with mercaptosuccinyl bovine serum albumin (MS… 
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