Corpus ID: 143430294

Development of Diet-Induced Insulin Resistance in Drosophila melanogaster and Characterization of the Anti-Diabetic Effects of Resveratrol and Pterostilbene

@inproceedings{Dhar2018DevelopmentOD,
  title={Development of Diet-Induced Insulin Resistance in Drosophila melanogaster and Characterization of the Anti-Diabetic Effects of Resveratrol and Pterostilbene},
  author={A. Dhar and Maryam Syed and D. Romero},
  year={2018}
}
million people are affected in the US alone (1). T2DM is characterized by a decrease in cellular sensitivity to the insulin peptide hormone, resulting in a detrimental accumulation of glucose in the bloodstream where it is unable to be utilized for metabolism and storage purposes. High blood glucose levels have the potential to trigger fatal cardiovascular diseases, extensive organ damage, and neuropathy (2). Given the rising rates of T2DM and the severe health implications associated with it… Expand

Figures and Tables from this paper

References

SHOWING 1-10 OF 16 REFERENCES
High Sugar-Induced Insulin Resistance in Drosophila Relies on the Lipocalin Neural Lazarillo
TLDR
The results indicate that insulin resistance shares common molecular mechanisms in flies and human and that Drosophila could emerge as a powerful genetic system to study some aspects of this complex syndrome. Expand
Functional implications of Drosophila insulin-like peptides in metabolism, aging, and dietary restriction
TLDR
Recent findings on the importance of conserved DILPs in metabolic homeostasis, DR, and aging are highlighted, providing strong evidence for the use of DILP in modeling metabolic disorders such as diabetes and hyperinsulinemia in the fly that could further the understanding of the underlying processes and identify therapeutic strategies to treat them. Expand
Diabetic larvae and obese flies-emerging studies of metabolism in Drosophila.
TLDR
This research establishes a new foundation for using this simple genetic model system to define the basic regulatory mechanisms that underlie metabolic homeostasis and holds the promise of providing new insights into the causes and treatments of critical human disorders such as diabetes and obesity. Expand
Overexpression of Sir2 in the adult fat body is sufficient to extend lifespan of male and female Drosophila
TLDR
It is found that moderate Sir2 overexpression in the fat body during adulthood only can promote longevity in both sexes by roughly 13 %, and additional independent evidence is provided for the concept of Sir2 as a longevity gene and as a promising pharmacological target to cure age-related diseases. Expand
dSir2 deficiency in the fatbody, but not muscles, affects systemic insulin signaling, fat mobilization and starvation survival in flies
TLDR
The results highlight the role of dSir2 in mobilizing fat reserves and demonstrate that its functions in the adult fatbody are crucial for starvation survival, and highlight the central role that fatbody d Sir2 plays in linking metabolism to organismal physiology and its importance for survival. Expand
AMPK and SIRT1: a long-standing partnership?
  • N. Ruderman, X. Xu, +4 authors Y. Ido
  • Biology, Medicine
  • American journal of physiology. Endocrinology and metabolism
  • 2010
TLDR
The evidence that AMPK and SIRT1 both regulate each other and share many common target molecules is examined and the possibility that their dysregulation predisposes to disorders such as type 2 diabetes and atherosclerotic cardiovascular disease is discussed. Expand
Oxidative stress and diabetic complications.
TLDR
Athrosclerosis and cardiomyopathy in type 2 diabetes are caused in part by pathway-selective insulin resistance, which increases mitochondrial ROS production from free fatty acids and by inactivation of antiatherosclerosis enzymes by ROS. Expand
A Review of Pterostilbene Antioxidant Activity and Disease Modification
TLDR
The antioxidant properties of pterostilbene and its relationship to common disease pathways are explored and a summary of the clinical potential is given in the prevention and treatment of various medical conditions. Expand
Autonomous Control of Cell and Organ Size by CHICO, a Drosophila Homolog of Vertebrate IRS1–4
TLDR
The similarities of the growth defects caused by mutations in chico and the insulin receptor gene in Drosophila and by perturbations of the insulin/IGF1 signaling pathway in vertebrates suggest that this pathway plays a conserved role in the regulation of overall growth by controling cell size, cell number, and metabolism. Expand
Pharmacokinetics, oral bioavailability, and metabolic profile of resveratrol and its dimethylether analog, pterostilbene, in rats
TLDR
Pterostilbene demonstrates greater bioavailability and total plasma levels of both the parent compound and metabolites than does resveratrol when administered orally, suggesting that the in vivo biological activity of equimolar doses of pterostILbene may be greater than that of resver atrol. Expand
...
1
2
...