Development of DNA-based radiopharmaceuticals carrying Auger-electron emitters for antigene radiotherapy.

@article{Sedelnikova2001DevelopmentOD,
  title={Development of DNA-based radiopharmaceuticals carrying Auger-electron emitters for antigene radiotherapy.},
  author={Olga A. Sedelnikova and A N Luu and Valeri N. Karamychev and Igor G. Panyutin and Ronald D. Neumann},
  journal={International journal of radiation oncology, biology, physics},
  year={2001},
  volume={49 2},
  pages={391-6}
}
PURPOSE Antigene radiotherapy (AR) is based on targeting localized radiodamage to specific sites in the genome by using sequence-specific triplex-forming oligonucleotides (TFO) to carry Auger-electron-emitters (A-Ettr) such as Iodine-125 (125I) to the target gene sequence. The radiodecay of an A-Ettr produces a cascade of low-energy electrons and creates a highly positively-charged daughter atom; delivered by a TFO, it should produce double-strand breaks (dsb) localized to the specific DNA… CONTINUE READING