Development of Clickable Monophosphoryl Lipid A Derivatives toward Semisynthetic Conjugates with Tumor-Associated Carbohydrate Antigens.

@article{Ziaco2017DevelopmentOC,
  title={Development of Clickable Monophosphoryl Lipid A Derivatives toward Semisynthetic Conjugates with Tumor-Associated Carbohydrate Antigens.},
  author={Marcello Ziaco and Sabina G{\'o}rska and Serena Traboni and Agnieszka Razim and Angela Casillo and Alfonso Iadonisi and Andrzej Gamian and Maria Michela Corsaro and Emiliano Bedini},
  journal={Journal of medicinal chemistry},
  year={2017},
  volume={60 23},
  pages={9757-9768}
}
A semisynthetic strategy to obtain monophosphoryl lipid A derivatives equipped with clickable (azide, alkyne, double bond, or thiol precursor) moieties, starting from the native lipid A isolated from Escherichia coli, is presented. These lipid A derivatives can be conjugated with other interesting biomolecules, such as tumor-associated carbohydrate antigens… CONTINUE READING