Development of Clade-Specific and Broadly Reactive Live Attenuated Influenza Virus Vaccines against Rapidly Evolving H5 Subtype Viruses.

Abstract

We have developed pandemic live attenuated influenza vaccines (pLAIVs) against clade 1 H5N1 viruses on an Ann Arbor cold-adapted (ca) backbone that induced long-term immune memory. In 2015, many human infections caused by a new clade (clade 2.2.1.1) of goose/Guangdong (gs/GD) lineage H5N1 viruses were reported in Egypt, which prompted updating of the H5N1… (More)
DOI: 10.1128/JVI.00547-17

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Cite this paper

@article{Boonnak2017DevelopmentOC, title={Development of Clade-Specific and Broadly Reactive Live Attenuated Influenza Virus Vaccines against Rapidly Evolving H5 Subtype Viruses.}, author={Kobporn Boonnak and Yumiko Matsuoka and Weijia Wang and Amorsolo L. Suguitan and Zhongying Chen and Myeisha Paskel and Mariana Baz and Ian Moore and Hong Jin and Kanta Subbarao}, journal={Journal of virology}, year={2017}, volume={91 15} }