Development of CYP2D6 and CYP3A4 in the First Year of Life

@article{Johnson2008DevelopmentOC,
  title={Development of CYP2D6 and CYP3A4 in the First Year of Life},
  author={Trevor N Johnson and Geoffrey T Tucker and Amin Rostami-Hodjegan},
  journal={Clinical Pharmacology \& Therapeutics},
  year={2008},
  volume={83}
}
methadone requirements. We agree that further research is required to investigate this discrepancy between the observations of the two studies, particularly with patient groups receiving comparable daily doses of methadone. In addition, the clinical usefulness of other markers, such as plasma concentrations and pharmacodynamic responses to methadone, should also be considered as a more appropriate reflection of how much methadone is reaching the site of action, as opposed to a daily dose which… 

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