Development of CD8 alpha alpha+ intestinal intraepithelial T cells in beta 2-microglobulin- and/or TAP1-deficient mice.

@article{Fujiura1996DevelopmentOC,
  title={Development of CD8 alpha alpha+ intestinal intraepithelial T cells in beta 2-microglobulin- and/or TAP1-deficient mice.},
  author={Yoshihisa Fujiura and Mio Kawaguchi and Yasuko Kondo and Shunsaku Obana and Hideyuki Yamamoto and Masanobu Nanno and Hiromichi Ishikawa},
  journal={Journal of immunology},
  year={1996},
  volume={156 8},
  pages={2710-5}
}
The development of CD8+ intestinal intraepithelial T lymphocytes (IEL) was analyzed in mice that are deficient in the expression of MHC class I molecules, owing to either a mutated beta 2-microglobulin (beta 2m) gene or a mutated transporter associated with Ag processing 1 (TAP1) gene, and in mice doubly homozygous for beta 2m and TAPI mutations. In all mutant mice, the population size of major CD8 alpha alpha+ and CD8 alpha beta+ alpha beta-IEL subsets was reduced drastically, and this… CONTINUE READING
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