Development of CD27+ marginal zone B cells requires GALT.

  title={Development of CD27+ marginal zone B cells requires GALT.},
  author={Venkata A. Yeramilli and Katherine L. Knight},
  journal={European journal of immunology},
  volume={43 6},
In species other than mouse, little is known about the origin and development of marginal zone (MZ) B cells. Using cross-reactive antibodies, we identified and characterized splenic MZ B cells in rabbits as CD27(+) CD23(-). In rabbits in which organized gut-associated lymphoid tissue (GALT) was surgically removed at birth, we found only CD23(+) follicular (FO) B cells and almost no CD27(+) MZ B cells in the spleen, indicating that GALT is required for the development of splenic MZ B cells… CONTINUE READING