Development of Branched Poly(5-Amino-1-pentanol-co-1,4-butanediol Diacrylate) with High Gene Transfection Potency Across Diverse Cell Types.

@article{Zhou2016DevelopmentOB,
  title={Development of Branched Poly(5-Amino-1-pentanol-co-1,4-butanediol Diacrylate) with High Gene Transfection Potency Across Diverse Cell Types.},
  author={Dezhong Zhou and Yongsheng Gao and Jonathan O'Keeffe Ahern and A Sigen and Qian Xu and Xiaobei Huang and Udo Greiser and Wenxin Wang},
  journal={ACS applied materials & interfaces},
  year={2016},
  volume={8 50},
  pages={
          34218-34226
        }
}
One of the most significant challenges in the development of polymer materials for gene delivery is to understand how topological structure influences their transfection properties. Poly(5-amino-1-pentanol-co-1,4-butanediol diacrylate) (C32) has proven to be the top-performing gene delivery vector developed to date. Here, we report the development of branched poly(5-amino-1-pentanol-co-1,4-butanediol diacrylate) (HC32) as a novel gene vector and elucidate how the topological structure affects… CONTINUE READING
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