Development of Approaches to Improve Cell Survival in Myoblast Transfer Therapy

  title={Development of Approaches to Improve  Cell Survival in Myoblast Transfer Therapy },
  author={Zhuqing Qu and Levent Balkir and Judith C.T. van Deutekom and P. David Robbins and Ryan Pruchnic and Johnny Huard},
  journal={The Journal of Cell Biology},
  pages={1257 - 1267}
Myoblast transplantation has been extensively studied as a gene complementation approach for genetic diseases such as Duchenne Muscular Dystrophy. This approach has been found capable of delivering dystrophin, the product missing in Duchenne Muscular Dystrophy muscle, and leading to an increase of strength in the dystrophic muscle. This approach, however, has been hindered by numerous limitations, including immunological problems, and low spread and poor survival of the injected myoblasts. We… CONTINUE READING

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