Development of Adenoviral Delivery Systems to Target Hepatic Stellate Cells In Vivo

@inproceedings{Reetz2013DevelopmentOA,
  title={Development of Adenoviral Delivery Systems to Target Hepatic Stellate Cells In Vivo},
  author={Julia Reetz and Berit Genz and Claudia Meier and Bhavani S. Kowtharapu and Franziska Timm and Brigitte Vollmar and Ottmar Herchenr{\"o}der and Kerstin Abshagen and Brigitte M. P{\"u}tzer},
  booktitle={PloS one},
  year={2013}
}
Hepatic stellate cells (HSCs) are known as initiator cells that induce liver fibrosis upon intoxication or other noxes. Deactivation of this ongoing remodeling process of liver parenchyma into fibrotic tissue induced by HSCs is an interesting goal to be achieved by targeted genetic modification of HSCs. The most widely applied approach in gene therapy is the utilization of specifically targeted vectors based on Adenovirus (Ad) serotype 5. To narrow down the otherwise ubiquitous tropism of… CONTINUE READING
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