Development of 5‐HT1A receptor radioligands to determine receptor density and changes in endogenous 5‐HT

@article{Jagoda2006DevelopmentO5,
  title={Development of 5‐HT1A receptor radioligands to determine receptor density and changes in endogenous 5‐HT},
  author={E. Jagoda and L. Lang and Joji Tokugawa and A. Simmons and Y. Ma and C. Contoreggi and D. Kiesewetter and W. Eckelman},
  journal={Synapse},
  year={2006},
  volume={59}
}
  • E. Jagoda, L. Lang, +5 authors W. Eckelman
  • Published 2006
  • Biology, Medicine
  • Synapse
  • [18F]FCWAY and [18F]FPWAY, analogues of the high affinity 5‐HT1A receptor (5‐HT1AR) antagonist WAY100635, were evaluated in rodents as potential radiopharmaceuticals for determining 5‐HT1AR density and changes in receptor occupancy due to changes in endogenous serotonin (5‐HT) levels. The in vivo hippocampus specific binding ratio [(hippocampusuptake/cerebellumuptake)−1] of [18F]FPWAY was decreased to 32% of the ratio of [18F]FCWAY, indicating that [18F]FPWAY has lower affinity than [18F]FCWAY… CONTINUE READING
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