Development of 3D Microfluidic Device to Study Endothelial-to-Mesenchymal Transformation

@article{Mina2013DevelopmentO3,
  title={Development of 3D Microfluidic Device to Study Endothelial-to-Mesenchymal Transformation},
  author={Sara Mina and Gretchen J Mahler and Wei Wang and Pong-Yu Huang},
  journal={2013 39th Annual Northeast Bioengineering Conference},
  year={2013},
  pages={221-222}
}
Our research objective is to identify the role of mechanobiology on endothelial-to-mesenchymal transformation (EndMT) by examining endothelial cell response to changes in the mechanical environment using microfluidic devices. Endothelial cells line all blood-contacting surfaces of the circulatory system and are able to sense and respond to mechanical and biochemical signals. EndMT begins when a subset of endothelial cells delaminate from the cell monolayer, lose cell-cell contacts, gain… CONTINUE READING