Development of 3D Chromatin Texture Analysis Using Confocal Laser Scanning Microscopy

@inproceedings{Huisman2005DevelopmentO3,
  title={Development of 3D Chromatin Texture Analysis Using Confocal Laser Scanning Microscopy},
  author={A. Huisman and Lennert S. Ploeger and Hub F. J. Dullens and Neal M. Poulin and William E. Grizzle and Paul J van Diest},
  booktitle={Cellular oncology : the official journal of the International Society for Cellular Oncology},
  year={2005}
}
INTRODUCTION Analysis of nuclear texture features as a measure of nuclear chromatin changes has been proven to be useful when measured on thin (5-6 microm) tissue sections using conventional 2D bright field microscopy. The drawback of this approach is that most nuclei are not intact because of those thin sections. Confocal laser scanning microscopy (CLSM) allows measurements of texture in 3D reconstructed nuclei. The aim of this study was to develop 3D texture features that quantitatively… CONTINUE READING

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