Development of (99m)Tc-labeled asymmetric urea derivatives that target prostate-specific membrane antigen for single-photon emission computed tomography imaging.

@article{Kimura2016DevelopmentO,
  title={Development of (99m)Tc-labeled asymmetric urea derivatives that target prostate-specific membrane antigen for single-photon emission computed tomography imaging.},
  author={Hiroyuki Kimura and Sotaro Sampei and Daiko Matsuoka and Naoya Harada and Hiroyuki Watanabe and Kenji Arimitsu and Masahiro Ono and Hideo Saji},
  journal={Bioorganic & medicinal chemistry},
  year={2016},
  volume={24 10},
  pages={
          2251-6
        }
}
Prostate-specific membrane antigen (PSMA) is expressed strongly in prostate cancers and is, therefore, an attractive diagnostic and radioimmunotherapeutic target. In contrast to previous reports of PMSA-targeting (99m)Tc-tricarbonyl complexes that are cationic or lack a charge, no anionic (99m)Tc-tricarbonyl complexes have been reported. Notably, the hydrophilicity conferred by both cationic and anionic charges leads to rapid hepatobiliary clearance, whereas an anionic charge might better… CONTINUE READING