Development by self-digestion: molecular mechanisms and biological functions of autophagy.

@article{Levine2004DevelopmentBS,
  title={Development by self-digestion: molecular mechanisms and biological functions of autophagy.},
  author={Beth Levine and Daniel J Klionsky},
  journal={Developmental cell},
  year={2004},
  volume={6 4},
  pages={463-77}
}
Autophagy is the major cellular pathway for the degradation of long-lived proteins and cytoplasmic organelles. It involves the rearrangement of subcellular membranes to sequester cargo for delivery to the lysosome where the sequestered material is degraded and recycled. For many decades, it has been known that autophagy occurs in a wide range of eukaryotic organisms and in multiple different cell types during starvation, cellular and tissue remodeling, and cell death. However, until recently… CONTINUE READING
Highly Influential
This paper has highly influenced 49 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 1,483 extracted citations

The emerging role of autophagy in plant pathogen attack and host defence.

Current opinion in plant biology • 2009
View 8 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…