Development by self-digestion: molecular mechanisms and biological functions of autophagy.

  title={Development by self-digestion: molecular mechanisms and biological functions of autophagy.},
  author={Beth Levine and Daniel J Klionsky},
  journal={Developmental cell},
  volume={6 4},
Autophagy is the major cellular pathway for the degradation of long-lived proteins and cytoplasmic organelles. It involves the rearrangement of subcellular membranes to sequester cargo for delivery to the lysosome where the sequestered material is degraded and recycled. For many decades, it has been known that autophagy occurs in a wide range of eukaryotic organisms and in multiple different cell types during starvation, cellular and tissue remodeling, and cell death. However, until recently… CONTINUE READING
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