OBJECTIVE To evaluate the reliability and validity of Neurologic Quality of Life (NeuroQOL) item banks that assess quality-of-life (QOL) domains not typically included in poststroke measures. DESIGN Secondary analysis of item responses to selected NeuroQOL domains. SETTING Community. PARTICIPANTS Community-dwelling stroke survivors (n=111) who were at least 12 months poststroke. INTERVENTIONS Not applicable. MAIN OUTCOME MEASURES Five measures developed for 3 NeuroQoL domains: ability to participate in social activities, satisfaction with participation in social activities, and positive psychologic function. RESULTS A single bank was developed for the positive psychologic function domain, but 2 banks each were developed for the ability-to-participate and satisfaction-with-participation domains. The resulting item banks showed good psychometric properties and external construct validity with correlations with the legacy instruments, ranging from .53 to .71. Using these measures, stroke survivors in this sample reported an overall high level of QOL. CONCLUSIONS The NeuroQoL-derived measures are promising and valid methods for assessing aspects of QOL not typically measured in this population.