Development and validation of liquid chromatography-Tandem mass spectrometry method for determination of amlodipine in human plasma and its application


A sensitive liquid chromatography tandem mass spectrometry method was developed to quantify amlodipine in human plasma. Alkalinized plasma spiked with desipramine, an internal standard, was extracted by liquid-liquid extraction and evaporated an organic part to dryness. The residue was reconstituted and injected into an Acquity Ultra Performance LCTM… (More)

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