Development and validation of liquid chromatography tandem mass spectrometry methods for the determination of gentamicin, lincomycin, and spectinomycin in the presence of their impurities in pharmaceutical formulations.

@article{VucieviPrceti2011DevelopmentAV,
  title={Development and validation of liquid chromatography tandem mass spectrometry methods for the determination of gentamicin, lincomycin, and spectinomycin in the presence of their impurities in pharmaceutical formulations.},
  author={Katarina Vuci{\'c}evi{\'c}-Prceti{\'c} and Robert Cserven{\'a}k and Niko Radulovi{\'c}},
  journal={Journal of pharmaceutical and biomedical analysis},
  year={2011},
  volume={56 4},
  pages={736-42}
}
Liquid chromatography with tandem mass spectrometry (LC/MS/MS) methods for the determination of gentamicin, lincomycin and spectinomycin in the presence of their impurities were developed and tested. Chromatographic separations were achieved using gradient elution on a C18 column. All components were ionized by positive-ion electrospray and detected by multi reaction monitoring (MRM) with an LC-tandem mass spectrometer. Calibration curves were linear with correlation coefficients better than 0… CONTINUE READING
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