Development and validation of bioanalytical methods for imidafenacin (KRP-197/ONO-8025) and its metabolites in human urine by using liquid chromatography-tandem mass spectrometry.

@article{Masuda2007DevelopmentAV,
  title={Development and validation of bioanalytical methods for imidafenacin (KRP-197/ONO-8025) and its metabolites in human urine by using liquid chromatography-tandem mass spectrometry.},
  author={Yuichi Masuda and Norihiro Kanayama and Shigeru Manita and Satoshi Ohmori and Tsuyoshi Ooie},
  journal={Biomedical chromatography : BMC},
  year={2007},
  volume={21 9},
  pages={
          940-8
        }
}
New bioanalytical methods have been developed for the determination of imidafenacin (KRP-197/ONO-8025, IM), a novel antimuscarinic drug developed for the treatment of overactive bladder, and its metabolites, M-2, M-3, M-4, M-6 and M-8 (method 1), M-5 and M-9 (method 2) in human urine by using liquid chromatography-tandem mass spectrometry. In each method, the urine sample was extracted by solid-phase extraction, separated on a semi-micro high-performance liquid chromatography column using… CONTINUE READING
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