Development and validation of an in vivo Candida albicans biofilm denture model.

@article{Nett2010DevelopmentAV,
  title={Development and validation of an in vivo Candida albicans biofilm denture model.},
  author={Jeniel E Nett and Karen Marchillo and Carol A. Spiegel and David R Andes},
  journal={Infection and immunity},
  year={2010},
  volume={78 9},
  pages={
          3650-9
        }
}
The most common form of oral candidiasis, denture-associated stomatitis, involves biofilm growth on an oral prosthetic surface. Cells in this unique environment are equipped to withstand host defenses and survive antifungal therapy. Studies of the biofilm process on dentures have primarily been limited to in vitro models. We developed a rodent acrylic denture model and characterized the Candida albicans and mixed oral bacterial flora biofilm formation, architecture, and drug resistance in vivo… CONTINUE READING

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