Development and validation of an LC–ESI–MS/MS method for simultaneous determination of levodopa, dopamine, L-α-methyldopa and 3-O-methyldopa in rat plasma

@article{Cho2012DevelopmentAV,
  title={Development and validation of an LC–ESI–MS/MS method for simultaneous determination of levodopa, dopamine, L-α-methyldopa and 3-O-methyldopa in rat plasma},
  author={Young Ah Cho and Semin Park and On Nuri Seo and Sung Woo Jeong and Woo-Kon Lee and Chi Yeon Kim and Soo Taek Kim and Myung Je Cho and Sung Chul Shin},
  journal={Journal of Pharmaceutical Investigation},
  year={2012},
  volume={42},
  pages={361-368}
}
Parkinson’s disease (PD) is a progressive degenerative disorder of the central nervous system. Levodopa (L-dopa), dopamine precursor is the most effective therapeutic drug for PD patients. Levodopa (LDP) and its three metabolites in rat plasma were determined using high performance liquid chromatography coupled with tandem mass spectrometry (LC–MS/MS… CONTINUE READING