Development and validation of an HPLC-DAD method for bis(12)-hupyridone and its application to a pharmacokinetic study.

@article{Yu2009DevelopmentAV,
  title={Development and validation of an HPLC-DAD method for bis(12)-hupyridone and its application to a pharmacokinetic study.},
  author={Hua Yu and Wen Ming Li and Man C. Cheung and Zhong Zuo and Paul R Carlier and Ze Gu and Kelvin Chan and Min Kyoo Kang Rui Huang and Yi Tao Wang and Yi Fan Han},
  journal={Journal of pharmaceutical and biomedical analysis},
  year={2009},
  volume={49 2},
  pages={410-4}
}
A rapid and simple method of high performance liquid chromatography with UV detection for the quantification of bis(12)-hupyridone in rat blood has been developed and validated. Chromatographic separation was carried out in an Agilent Extend C(18) 5microm column (length, 250mm; inner diameter, 4.6mm) using a mixture of water-acetonitrile-trifluoroacetic acid (81:19:0.04, v/v/v) as the mobile phase at a flow rate of 1mL/min, with detection at 229nm. The method used for the bis(12)-hupyridone… CONTINUE READING
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